Therefore, it was considered to be rejected at a p valueof 0.05. It also strengthens tooth enamel by helping rebuild weak spots. J Non Cryst Solids. p values of<0.05 were considered as statistically significant. Width 17 Height 5 Depth 3.8 Show More Payment & Refunds J Evid Based Dent Pract. The clinical significance of this study can be highlighted by the fact that this was a person-centred clinical trial where patients were the prime focus where thepatients suffering from DH. Pro-argin resulted in the immediate treatment response and statistically significant (p<0.001) clinical reduction in DH than FCPS in the present study, as shown in Table 3. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste contains Sodium Fluoride (1450ppmF) the recommended fluoride level for effective caries prevention.4. YYYY Colgate-Palmolive Company. Tandkrmen har ett slipmedel som ger en mild polering och tar bort yttre flckar och fluor skyddar tnderna mot karies. Lasting relief with 2x daily continued brushing. 2010;11:32. All the treatment groups showed statistically significant improvement in DH with p<0.001 relative to baseline at all time points. Plugging the channels that lead to sensitive tooth nerves to help relieve sensitivity. The limitation of our study is that fluoridated dentifrice was used as a control which, although regarded as not possessing any desensitising effects. The main etiological factors are abrasion and erosion that may or may not be associated with gingival recession in DH. 4.4 5 0 198 198 Colgate Sensitive Pro-Relief Gum Therapy toothpaste helps instantly repair sensitive teeth and provides lasting protection against hypersensitivity. [10] examined the evidence for strontium acetate and Pro-argin in 2018, and their findings depicted low quality of evidence for strontium acetate on the Grading of Recommendations, Assessment, Development, and Evaluations system (GRADE). J Clin Periodontol. The study's primary objective was to investigate pain relief in one minute after topical application of Pro-argin and strontium acetate on sensitive teeth in DH. Size: 75ml (Approx.) J Dent. Colgate SENSITIVE Instant(Pro) Relief Enamel Repair Toothpaste 75ml (Pck 4,6,12) 15.99 to 39.99. To alleviate their tooth sensitivity problem, by using Colgate Sensitive Pro-Relief will give them lasting relief and they can drink ice water freely. Modified bass brushing method was demonstrated on the same model before the first application of dentifrices in the dental clinic. 2009;22(Spec No. The prevalence of DH was found to vary from about 5 to 62% owing to the use of different diagnostic and measuring tools and age groups in the published literature, with the best average estimate of 34% worldwide [3]. Colgate Sensitive Pro Relief Enamel Repair to strengthen weakened enamel and prevent enamel loss. Dentine hypersensitivity (DH) is a chronic condition with acute, transient pain in non-carious teeth that originates in response to thermal stimuli such as hot or cold, chemicals like acidic or sweet or salt, and mechanical stimuli due to exposure to dentinal tubules without any apparent clinical disease [1]. Though all bioactive agents have a significant treatment effect in reducing DH, there is currently no consensus on the unequivocal efficacy of any product or bioactive agent used for managing the condition due to huge variations and heterogeneity in the conduct of clinical trials on DH [6]. Aust Dent J. Moreover, the occluding potential of Pro-argin has also been ascertained in a previous in vitro analysis conducted by Lavender et al. 2017;30(4):2216. Another study by Hines et al. Docimo R et al. 2009;22:3A-7A. After six weeks, FCPS-based dentifrices showed greater clinical efficacy with mean scores (1.801.73) than other treatment arms for waterjet stimulated DH. Dentifrices-containing Pro-argin showed a significant reduction in DH with mean scores of (4.201.70) followed by strontium acetate (4.651.87) followed by FCPS (5.101.88) one minute after application. The Sensitive Pro-Relief Multi-Protection toothpaste by Colgate thoroughly cleans your teeth, while providing you with relief from sensitive tooth pain. Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian adults. It has stannous fluoride as an active ingredient. Colgate Sensitive Pro-Relief Multi Protection Toothpaste provides clinically proven instant and lasting relief for sensitive teeth For instant relief, apply directly to each sensitive tooth with finger tip and gently massage for 1 minute, up to twice daily TVC Category: Colgate Tooth Paste Benefits Clinically proven sensitivity relief. For best performance, keep cap closed when not in use. It remains a prevalent global disease with two different treatment modalities of home-care desensitisation with the over-the-counter (OTC) desensitisers such as potassium, Ingredients *Calcium carbonate *Water statement and Table 2 presents descriptive statistics of the primary analysis population as the primary statistical analysis was performed for 47 males and 81 females of age ranging from 18 to 50years with a mean age of 34.18.9. https://doi.org/10.17352/2394-8418.00003. In addition, patients were educated regarding the cause of the disease for prevention and awareness of oral hygiene measures, brushing techniques, and dietary influences in DH. 1 Nathoo et al. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. It revealed an immediate improvement with strontium acetate more than Pro-argin on SCASS. Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. Colgate Sensitive Pro-Relief Original Toothpaste This toothpaste gives you the freedom to forget about tooth sensitivity. Gillam D, Hill R, Samueli A. Bioactive glasses in the management of dentine hypersensitivity: a review. It is clinically proven for instant and lasting Sensitivity relief* How does it work? Post-hoc analysis revealed a significant reduction in DH scores in treatment arms compared to control on completing the six-week trial (p<0.05). The second objective of the current study was to directly compare the clinical efficacy of FCPS, Pro-argin technology, and strontium acetate-based dentifrices due to their similar mode of action and tubular occluding potential in managing DH [36, 37]. compared Colgate Sensitive Pro Relief to another leading brand that desensitizes with a 2% potassium ion formula. J Dent Res. [16] in a systematic review in 2015. Mahmoodi B, Wood R, Cook R. Protection and acid resistivity of bioactive-glasses, arginine and calcium silicate. The statistically significant change in mean scores of DH was observed with FCPS with p<0.05 relative to baseline for sustained relief from DH at follow-ups on day 3, week 2, week 4, and week 6, using clinical parameters of SCASS and VAS. [18] in a meta-analysis in 2020. This study investigated the relief from pain in DH in one minute after applying over the counter (OTC) dentifrices with Pro-Argin and strontium acetate and directly compared them with fluoro-calcium phospho-silicate (FCPS)-based dentifrices for immediate and sustained inhibition of painful stimulus provoking DH. J Clin Dent. A total of 128 participants completed the trial. Click & Collect. Oral dentifrices have been marketed for pain relief within a minute for DH. Participants were recalled at interim efficacy intervals of three days, two weeks, four weeks, and six weeks for assessment of sustained relief. After six weeks, Pro-argin-based dentifrices showed greater clinical efficacy with mean scores (2.151.92) than other treatment arms for mechanical stimulated DH. The participants with self-reported sensitivity in teeth were clinically diagnosed with DH. Exclusive Pro-Argin formula. The findings agreed with another in vitro trial by Mahmoodi et al. The second null hypothesis was that mean scores for pain due to DH among different treatment groups for sustained relief remains the same, and it was considered to be rejected at a p value0.05. Colgate Sensitive Pro Relief Teeth Whitening Sensitivity Toothpaste, 75ml 4.9 out of 5 stars 12 7 offers from SAR 33.95 Colgate Sensitive Pro Relief Base Instant Sensitivity Relief Toothpaste, 75ml 4.3 out of 5 stars 20 5 offers from SAR 31.25 Colgate Total 12 hour Protection Pro - Gum Health Toothpaste 75ml The secondary analysis population could be described as 20 participants per treatment group out of 35 enrolled in the six-week trial who responded to mechanical and water jet stimuli on VAS with scores of4 as secondary outcome measures. 4.2 5 0 221 221 Colgate Sensitive Pro-Relief Enamel Rebuild toothpaste helps instantly repair sensitive teeth and provides lasting protection against hypersensitivity. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. # In-vitro study, actual confocal images after 5 treatments. Another study by Hines et al. Paired sample T-test was used to compute mean scores to observe change relative to baseline at each time point. These then interact to form a complex with positive charge. SCASS and VAS were introduced on each visit as primary and secondary outcome measures, respectively. This site is intended for healthcare professionals only. Blocks the pain of sensitive teeth. Naturally, the researchers wondered whether it could help shield a person from acquiring the virus. Colgate Sensitive Pro-Relief It works by plugging the channels to block tooth sensitivity and with regular use. Colgate Sensitive Pro-Relief toothpastes have been formulated to provide instant and lasting relief from the pain associated with sensitive teeth. Colgate Sensitive Pro-Relief Complete Protection sensitivity toothpaste is clinically proven for instant and lasting relief from sensitivity pain. Colgate Sensitive Instant Relief Multiprotection Toothpaste gives you clinically proven lasting relief from sensitivity for 8 weeks when you use it twice a day. We found more change in pain scores of VAS used for mechanical stimuli with Pro-argin than FCPS as shown in Table 5 that could be relatable with a randomised controlled trial of FCPS and arginine based desensitizers reporting better treatment response of arginine than FCPS in the cold stimulated DH after two weeks to one month, subsequently [40]. SA was the principal investigator and has contributed to design, data acquisition, analysis, and interpretation, and drafted the manuscript. Prevalence of dentin hypersensitivity: systematic review and meta-analysis. With the exclusive Pro-Argin formula, it provides instant* and lasting** relief by plugging the channels to block tooth sensitivity. FCPS showed the highest reduction in DH on SCASS and VAS for waterjet stimuli with mean scores of (0.970.68) (1.801.73) and Pro-Argin on VAS for mechanical stimuli with mean scores of (2.151.92) in six weeks. Dentifrices-containing Pro-argin showed a significant reduction in DH with mean scores of (3.052.17) followed by strontium acetate (3.751.97) followed by FCPS (5.301.83) one minute after application. SEALS & REPAIRS: Pro-Argin technology helps to seal and repair the sensitive areas of teeth. Compend Contin Educ Dent. *with direct application and daily brushing. Poster #3406, July 2018 IADR. Pak Oral Dent J. Arshad, S., Zaidi, S.J.A. The burden of dentine hypersensitivity. Another study by Vu Pham and Anh Nguyen reported clinical improvement in DH by 38.9% on SCASS and 40.2% on VAS for mechanical stimulated DH immediately after application of Pro-argin [25]. These dentifrices were extracted in a plain tube by the dental assistant from commercial packing and labelled with treatment codes to keep the principal investigator and participants blinded at the time of treatment assignment. Colgate-Palmolive Company 2018. Colgate Sensitive Pro-Relief toothpaste is a revolutionary and one-of-its kind remedy that can provide consumers suffering from Sensitivity the much needed instant and long lasting relief . Plus it has the freshness you trust from Colgate! Brush twice daily. Further, it leaves a durable, mineral-enriched layer on the exposed dentin to help protect against future dentin hypersensitivity. Identifier NCT 04249336. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. A total of 140 participants were initially enrolled and randomised into the four treatment arms, with thirty-five in each group. With regular use, the Pro-Argin formula builds a long-lasting protective barrier that acts like a seal against sensitivity. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Colgate Sensitive Instant Relief Repair & Prevent Toothpaste starts blocking sensitivity pain instantly*. 5 Hines D et al. 2016;8:114. We provided oral hygiene instructions and ways of relieving their pain from DH to improve their quality of life. 90 sold. For lsting relief, apply to a gentle toothbrush making sure to brush all . 2020;20(3):101460. The loss of tooth enamel is the most common cause of tooth sensitivity and is not affected by cavities, gum disease, or other problems. Researchers have investigated the clinical efficacy of popular propriety occluding dentifrices containing Pro-argin, strontium acetate, and FCPS formulations for treating DH and have found no adverse effects. Effect of dentin hypersensitivity treatment on oral health related quality of lifea systematic review and meta-analysis. Holland G, Narhi M, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Table 4 demonstrates a comparison between treatment groups observing better clinical efficacy in managing DH on SCASS. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste is an everyday toothpaste. Indian J Dent Sci. Last updated on May 11, 2021. https://clinicaltrials.gov/ct2/show/NCT04249336. Therefore, the first null hypothesis was that mean scores for pain due to DH among different treatment groups for immediate relief remain. Clinically proven amino acid formula with Pro-Argin technology to provide sensitivity relief. 2018;9(3):3306. YYYY Colgate-Palmolive Company. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. J Dent. Lg i kurv. All rights reserved. Use regularly to enjoy long-lasting relief from sensitivity*. The findings have revealed that both statistically and clinically significant change in mean scores of DH was observed with Pro-argin and 8% strontium acetate with p<0.05 relative to baseline for immediate and sustained relief from DH using clinical parameters of SCASS and VAS. Sriranganathan D, Chen X, Hing KA, Kanwal N, Hill RG. Results of our study, together with the results of the previous studies, confirm the immediate clinical efficacy of Pro-argin for the relief of DH. Desensitizing toothpastes depolarize the nerves to reduce pain signals to the brain, while occlusives block the dentin tubules to prevent painful stimuli affecting dentinal fluids. Terms and Conditions, Table 5 presents the change in the mean scores of VAS against mechanical stimulus from baseline to subsequent efficacy interval within each treatment arm. Helps protect teeth against cavities and promotes healthy gums (with regular brushing). Colgate Sensitive Pro Relief was found to achieve 91% dentin occlusion, compared to 67% for the stannous fluoride toothpaste. Google Scholar. Get the freedom to forget about tooth sensitivity with Colgate Sensitive Pro-Relief Complete Protection Toothpaste. Pro-Argin Technology with arginine and an insoluble calcium compound, zinc and 1450ppm fluoride. Wilcoxon Signed-Rank Test was used to compute mean scores relative to baseline at each time point. According to Holland's guidelines of conducting a trial for managing DH, two diagnostic tools are sufficient for quantitative assessment of the clinical efficacy of desensitisers. All rights reserved. YES Somewhat No J Clin Exp Dent. A meta-analysis by Yang et al. Ayad F, Ayad N, Zhang YP, DeVizio W, Cummins D, Mateo LR. Comparative evaluation of the efficacy of three commercially available toothpastes on dentin hypersensitivity reduction: an 8-week clinical study. A randomised clinical trial on the efficacy of 5% fluorocalcium phosphosilicate-containing novel bioactive glass toothpaste. 75 ml. This clinical trial has not included a run-in or washout period before the test phase due to time constraints and compliance of the potential participants. Can be used after the Colgate Sensitive Pro-Relief Desensitizing Paste. Samueli A, Hill R, Gillam D. Bioactive glasses in the management of dentine hypersensitivity: a review. Therefore, in the current study, we used a dental explorer and the air blast and water jet stimuli from the triple syringe of the dental unit for testing DH to control the subjective variations in treatment response. Published literature [16, 31, 43] has determined that all previous trials on treating DH were conducted on smaller samples, which might have prevented the results from being extrapolated on the general population. Our study included an Asian population, and most of the published literature was associated with the Caucasian population. Anvnd tv gnger dagligen. Fordeler Colgate SENSITIVE INSTANT Relief tannkrem er klinisk dokumentert virke i lpet av sekunder samtidig som den beskytter tannen mot at smerten skal komme tilbake. In addition, one-Way ANOVA with Post Hoc Tukey for pair-wise comparison was used to compare treatment groups computing percent change from baseline with formula (post-application mean scores-baseline mean scores/baseline mean scores). Work with Colgate Professional to help provide better oral care to your patients. These fluorapatite crystals were less susceptible to acidic dissolution than hydroxyapatite crystals and thus were more desirable [13]. 2010;23(Spec No A):14A-9A. Compend Contin Educ Dent. The strength of this study was that participants were randomised into four treatment groups to generalise the results for the population [32]. Am J Dent.